Altered hematopoietic cell gene expression precedes development of therapy-related myelodysplasia/acute myeloid leukemia and identifies patients at risk.

نویسندگان

  • Liang Li
  • Min Li
  • Canlan Sun
  • Liton Francisco
  • Sujata Chakraborty
  • Melanie Sabado
  • Tinisha McDonald
  • Janelle Gyorffy
  • Karen Chang
  • Shirong Wang
  • Wenhong Fan
  • Jiangning Li
  • Lue Ping Zhao
  • Jerald Radich
  • Stephen Forman
  • Smita Bhatia
  • Ravi Bhatia
چکیده

Therapy-related myelodysplasia or acute myeloid leukemia (t-MDS/AML) is a major complication of cancer treatment. We compared gene expression in CD34+ cells from patients who developed t-MDS/AML after autologous hematopoietic cell transplantation (aHCT) for lymphoma with controls who did not develop t-MDS/AML. We observed altered gene expression related to mitochondrial function, metabolism, and hematopoietic regulation in pre-aHCT samples from patients who subsequently developed t-MDS/AML. Progression to overt t-MDS/AML was associated with additional alterations in cell-cycle regulatory genes. An optimal 38-gene PBSC classifier accurately distinguished patients who did or did not develop t-MDS/AML in an independent group of patients. We conclude that genetic programs associated with t-MDS/AML are perturbed long before disease onset, and accurately identify patients at risk for this complication.

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عنوان ژورنال:
  • Cancer cell

دوره 20 5  شماره 

صفحات  -

تاریخ انتشار 2011